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Transferrin Receptor Monoclonal Antibody (R17217.1.4), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17923
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
R17217.1.4
Immunogen
Induced Friend Erythroleukemia 745.6 cell extracts
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
50 µg
Purification
Protein G
Storage buffer
PBS with 4-5mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD71; mammary tumor virus receptor 1; transferrin receptor; unnamed protein product
Gene Aliases: 2610028K12Rik; CD71; E430033M20Rik; Mtvr1; p90; TFR; TFR1; TR; Trfr
UniProt ID: (Mouse) Q62351
Entrez Gene ID: (Mouse) 22042
response to hypoxia
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
acute-phase response
cell surface receptor signaling pathway
response to nutrient
response to iron ion
response to manganese ion
positive regulation of gene expression
negative regulation of mitochondrial fusion
osteoclast differentiation
positive regulation of B cell proliferation
positive regulation of protein complex assembly
receptor internalization
response to retinoic acid
transferrin transport
iron ion transmembrane transport
intracellular signal transduction
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of isotype switching
response to copper ion
multicellular organismal iron ion homeostasis
cellular response to iron ion
cellular response to xenobiotic stimulus
regulation of postsynaptic membrane neurotransmitter receptor levels
positive regulation of protein localization to nucleus
cellular response to leukemia inhibitory factor
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