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Invitrogen
OLFM1 Monoclonal Antibody (2G12-1B3)
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Product Details
MA5-21044
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2G12-1B3
Immunogen
OLFM1 (AAH00189, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.2-1.0 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: MPGRWRWQRD MHPARKLLSL LFLILMGTEL TQNKRENKAE KMGGPESERK TTGEKTLNEL PLFCLEAHAG SLALPRMCSP NPNPAVGLCR PAYPQSPSPG AAQTISQSLL ERFCMASRRE VFLAPGRPGG GWWLCTVAGQ MHSFMCTHTH THAHTGEQIP AEKSQPGPD
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuroblastoma protein; Neuronal olfactomedin-related ER localized protein; Noelin; olfactomedin related ER localized protein; Olfactomedin-1; pancortin 1; unnamed protein product
Gene Aliases: AMY; NOE1; NOEL1; NOELIN1; OlfA; OLFM1
UniProt ID: (Human) Q99784
Entrez Gene ID: (Human) 10439
atrioventricular valve formation
signal transduction
nervous system development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
neuronal signal transduction
regulation of axon extension
positive regulation of apoptotic process
cardiac epithelial to mesenchymal transition
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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