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Invitrogen
OX40 Monoclonal Antibody (443318), APC
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FIGURE: 1 / 1
OX40 Antibody (MA5-23591) in Flow
Flow cytometry of OX40 in Human peripheral blood mononuclear cells (PBMCs) stained with Mouse Anti-Human CD3 PE‚conjugated Monoclonal Antibody. Samples were incubated in either (A) OX40 monoclonal antibody (Product # MA5-23591) or (B) Rat IgG2A Allophycocyanin Isotype Control.
Product Details
MA5-23591
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
443318
Immunogen
Mouse myeloma cell line NS0-derived recombinant human OX40/TNFRSF4 Leu29-Ala216
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, no cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFAS, rhGITR, rhHVEM, rhLT beta R, rhNGF R, rhRANK, rhRELT, rhTAJ, rhTNF RI, rhTNF RII, rhTRAIL, rhTRAIL R4, rhTRAIL R3, rhTWEAK R, or rhXEDAR is observed.
Target Information
OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; lymphoid activation antigene ACT35; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4
Gene Aliases: ACT35; CD134; IMD16; OX40; TNFRSF4; TXGP1L
UniProt ID: (Human) P43489
Entrez Gene ID: (Human) 7293
inflammatory response
immune response
multicellular organism development
positive regulation of B cell proliferation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
T cell proliferation
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
viral entry into host cell
positive regulation of immunoglobulin secretion
apoptotic signaling pathway
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