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Invitrogen
CD23 Monoclonal Antibody (691632), PE
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FIGURE: 1 / 1
CD23 Antibody (MA5-23612) in Flow
Flow cytometric analysis of mouse splenocytes were stained with Rat Anti-mouse B220/CD45R APC-conjugated Monoclonal Antibody and either (A) Rat Anti-mouse CD23/Fc epsilon RII PE-conjugated Monoclonal Antibody (Product # MA5-23612) or (B) Rat IgG2A Phycoerythrin Isotype Control.
Product Details
MA5-23612
Product Specifications
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
691632
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD23/Fcepsilon RII Glu50-Pro331
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Wet ice
RRID
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human (rh) Fc epsilon RIA or rhFc epsilon RIG is observed.
Target Information
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lymphomas. Functionally, CD23 is involved in B cell growth, differentiation, and IgE production. It interacts with CD21 and the alpha subunits of CD11b and CD11c, further influencing immune responses. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia, highlighting its importance in both normal immune function and disease states. This makes CD23 a valuable target for antibody customers interested in B-cell-related research and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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