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Invitrogen
IL1R2 Monoclonal Antibody (34141), APC
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FIGURE: 1 / 2
IL1R2 Antibody (MA5-23626) in Flow
Flow cytometry of IL1R2 in Human peripheral blood mononuclear cells (PBMCs), stimulated to induce Regulatory T Cells (Tregs) and gated on CD4+, were treated with 10 µg/mL Anti-CD3, 5 µg/mL Anti-CD28, 10 ng/mL Recombinant Human TGF‚β1 , and 20 ng/mL Recombinant Human IL‚2 for 48 hours and stained with Rat Anti-Human LRRC32/GARP PE‚conjugated Monoclonal Antibody. Samples were incubated in either (A) IL1R2 monoclonal antibody (Product # MA5-23626) or (B) Mouse IgG1 Allophycocyanin Isotype Control.
Product Details
MA5-23626
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
34141
Immunogen
Sf 21-derived recombinant human IL-1 RII Phe14-Glu343 (Ser56Gly and Glu297Gly)
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with ≤ 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
When used in combination with the biotinylated human IL-1 RII affinity purified polyclonal detection antibody in sandwich ELISAs, no significant cross-reactivity or interference was observed with recombinant human (rh) IL-1ra, rhIL-1 RI, recombinant mouse IL-1ra, or recombinant rat IL-1ra.
Target Information
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CDw121b; CD121 antigen-like family member B; CD121b; CDw121b; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL1 receptor type II variant 3; ILR2; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; Interleukin-1 receptor type II; type II interleukin-1 receptor, beta
Gene Aliases: CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2; IL1R2c; IL1RB
UniProt ID: (Human) P27930
Entrez Gene ID: (Human) 7850
immune response
cell surface receptor signaling pathway
negative regulation of protein processing
protein processing
cytokine-mediated signaling pathway
negative regulation of interleukin-1 alpha production
negative regulation of cytokine production involved in inflammatory response
negative regulation of interleukin-1-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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