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Invitrogen
IL-15 Monoclonal Antibody (34559), APC
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FIGURE: 1 / 1
IL-15 Antibody (MA5-23627) in Flow
Flow cytometry of IL-15 in Human peripheral blood monocytes. Resting (open histogram), or treated overnight with 1 µg/mL LPS (filled histogram), were stained with Mouse Anti-Human IL-15 APC-conjugated Monoclonal Antibody (Product # MA5-23627) or isotype control antibody (data not shown). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-23627
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
34559
Immunogen
E. coli-derived recombinant human IL-15 Asn49-Ser162
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with ≤ 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2, recombinant mouse IL-15, or rhIL-21 is observed.
Target Information
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HTLV-I R-IL-15 fusion gene; il 15; IL15; ILN; Interleukin; Interleukin15; lymphokine; M-IL-15; MGC9721; unnamed protein product
Gene Aliases: IL-15
UniProt ID: (Human) P40933
Entrez Gene ID: (Human) 3600
positive regulation of cytokine production
immune response
signal transduction
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
cell-cell signaling
positive regulation of cell proliferation
macrophage differentiation
positive regulation of interleukin-17 production
positive regulation of tissue remodeling
interleukin-15-mediated signaling pathway
positive regulation of T cell proliferation
neutrophil activation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phagocytosis
positive regulation of immune response
negative regulation of cold-induced thermogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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