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Invitrogen
GP130 Monoclonal Antibody (125623)
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FIGURE: 1 / 3
GP130 Antibody (MA5-23922) in ICC/IF
Immunofluorescence analysis of GP130 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with GP130 Monoclonal Antibody (125623) (Product # MA5-23922) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 (Product # A28... View More
Product Details
MA5-23922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
125623
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse gp130 Gln23-Glu617 (predicted)
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, no cross-reactivity with recombinant human gp130 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; LIF receptor/IL-6 receptor complex component; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha; soluble receptor
Gene Aliases: 5133400A03Rik; AA389424; BB405851; CD130; CDW130; D13Ertd699e; GP130; HIES4; HIES4A; HIES4B; IL-6RB; IL6ST; IMD94; sGP130; STWS2
UniProt ID: (Human) P40189, (Mouse) Q00560
Entrez Gene ID: (Human) 3572, (Mouse) 16195
cytokine receptor activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
ciliary neurotrophic factor receptor binding
interleukin-6 receptor binding
protein binding
coreceptor activity
growth factor binding
cytokine binding
interleukin-11 binding
interleukin-6 binding
protein tyrosine kinase activator activity
identical protein binding
interleukin-27 receptor activity
scaffold protein binding
protein heterodimerization activity
transmembrane signal receptor
positive regulation of acute inflammatory response
positive regulation of adaptive immune response
glycogen metabolic process
signal transduction
JAK-STAT cascade
positive regulation of cell proliferation
regulation of Notch signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of cardiac muscle hypertrophy
cytokine-mediated signaling pathway
cell differentiation
response to cytokine
interleukin-11-mediated signaling pathway
oncostatin-M-mediated signaling pathway
positive regulation of T cell proliferation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
intestinal epithelial cell development
interleukin-6-mediated signaling pathway
negative regulation of interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
T-helper 17 cell lineage commitment
receptor signaling pathway via STAT
positive regulation of platelet aggregation
triglyceride mobilization
positive regulation of smooth muscle cell migration
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of cytosolic calcium ion concentration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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