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Invitrogen
FAM3A Monoclonal Antibody (358112)
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FIGURE: 1 / 5
FAM3A Antibody (MA5-24107) in WB
EBioMedicine 2019 -
Fig. 3 Endothelial FAM3A knockdown suppresses angiogenesis. (a) HUVECs were infected with adenovirus coding Scr shRNA or FAM3A shRNA for 24 h, and the FAM3A protein level was measured by western blotting. (b) Ad-Scr shRNA- and Ad-FAM3A shRNA-infected HUVECs were placed in plates coated with Matrigel and tubular structures were photographed. (n = 5 per group) Scale bar, 50 mum. (c) The proliferation of HUVEC... View More
Product Details
MA5-24107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
358112
Immunogen
Mouse myeloma cell line NS0-derived recombinant human FAM3A Phe34-Ser230
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse FAM3A is observed and no cross-reactivity with recombinant human (rh) FAM3B, rhFAM3C, or rhFAM3D is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
A novel cytokine-like gene family using structure-based methods to search for novel four-helix-bundle cytokines in genomics databases. There are four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. Northern analysis indicates that FAM3B is highly expressed in pancreas, FAM3D in placenta, and FAM3A and FAM3C in almost all tissues. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. Fam3a staining in capillary endothelium and endocardium of heart, as well as vascular endothelial staining in many other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2.19; Cytokine-like protein 2-19; family with sequence similarity 3 member A; Protein FAM3A; unnamed protein product
Gene Aliases: 2-19; 2.19; DLD; DXS560S; FAM3A; XAP-7
UniProt ID: (Human) P98173
Entrez Gene ID: (Human) 60343
glucose metabolic process
ATP biosynthetic process
mitochondrion organization
response to glucose
gene expression
antifungal humoral response
insulin secretion
calcium ion homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of antifungal innate immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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