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Invitrogen
NSD2 Monoclonal Antibody (CL1057)
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FIGURE: 1 / 7
NSD2 Antibody (MA5-24620) in ICC/IF
Immunofluorecent analysis of NSD2 in U-251 cells using NSD2 Monoclonal Antibody (CL1057) (Product # MA5-24620). Staining shows specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
Product Details
MA5-24620
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL1057
Immunogen
Recombinant protein fragment of Human NSD2 (Product #RP-91616).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Binds to an epitope located within the peptide sequence RVFNGEPGAHDAKLR as determined by overlapping synthetic peptides.
Target Information
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: contains SET domain; histone methyltransferase; MMSET type III; Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; trithorax/ash1-related protein 5; unnamed protein product; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 protein
Gene Aliases: KIAA1090; KMT3F; KMT3G; MMSET; NSD2; RAUST; REIIBP; TRX5; WHS; WHSC1
UniProt ID: (Human) O96028
Entrez Gene ID: (Human) 7468
DNA binding
chromatin binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
histone methyltransferase activity (H4-K20 specific)
sequence-specific DNA binding
metal ion binding
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K36 dimethyltransferase activity
histone H3K36 trimethyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
membranous septum morphogenesis
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
double-strand break repair
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
methylation
positive regulation of isotype switching to IgA isotypes
bone development
regulation of establishment of protein localization
regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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