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Invitrogen
H2A.ZK4ac Recombinant Rabbit Monoclonal Antibody (RM221)
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Product Details
MA5-24664
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM221
Immunogen
Acetyl-peptide corresponding to Acetyl-Histone H2A.Z (Lys4).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2-7.4, with 50% glycerol, 1% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts to Histone H2A.Z acetylated at Lysine 4 (K4ac). No cross reactivity with non-modified Lysine 4 or other acetylated Lysines in histone H2A
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11ac; Acetyl-Histone H2A.Z K4; Acetyl-Histone H2A.Z Lys4; H2A histone family member V; H2A histone family member Z; H2A.F/Z; H2A.Z variant histone 2; H2A.ZK5; H2A.ZK5ac; H2A.ZLys4ac; H2A/z; H2AFZ; H2AFZac; H2AZ histone; H2AZK11ac; H2AZK4ac; H2AZK7ac; H2AZLys4ac; histone (H2A.Z); histone H2A.F/Z; Histone H2A.V; Histone H2A.Z; purine-rich binding element protein B; unnamed protein product
Gene Aliases: H2A.z; H2A.Z-1; H2A.Z-2; H2A/z; H2AFV; H2AFZ; H2AV; H2AZ; H2AZ1; H2AZ2
UniProt ID: (Human) P0C0S5, (Human) Q71UI9
Entrez Gene ID: (Human) 3015, (Human) 94239
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
DNA binding
protein binding
structural constituent of chromatin
chromatin DNA binding
nucleosomal DNA binding
protein heterodimerization activity
binding, bridging
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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