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Invitrogen
NOR-1 Monoclonal Antibody (OTI5C2)
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FIGURE: 1 / 8
NOR-1 Antibody (MA5-26704) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human breast tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.0 was used. Following antigen retrieval, tissues were probed with a NR4A3 monoclonal antibody (Product # MA5-26704) at a dilution of 1:150.
Product Details
MA5-26704
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5C2
Immunogen
Human recombinant protein fragment corresponding to amino acids 332-626 of NR4A3 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; steroid/thyroid orphan receptor homolog gene; TEC receptor; Translocated in extraskeletal chondrosarcoma
Gene Aliases: CHN; CSMF; MINOR; NOR1; NR4A3; TEC
UniProt ID: (Human) Q92570
Entrez Gene ID: (Human) 8013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
protein kinase binding
histone acetyltransferase binding
glucocorticoid receptor binding
cAMP response element binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
mesoderm formation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
gastrulation
axon guidance
positive regulation of cardiac muscle hypertrophy
positive regulation of glucose transport
hippocampus development
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
adult behavior
positive regulation of mast cell cytokine production
smooth muscle cell apoptotic process
negative regulation of smooth muscle cell apoptotic process
intracellular signal transduction
common myeloid progenitor cell proliferation
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
inner ear morphogenesis
response to hydrogen peroxide
mast cell degranulation
negative regulation of neuron apoptotic process
cellular response to leptin stimulus
cellular respiration
fat cell differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
platelet-derived growth factor receptor signaling pathway
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
semicircular canal morphogenesis
positive regulation of epithelial cell proliferation
neuromuscular process controlling balance
neuron apoptotic process
vestibular reflex
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
cellular response to catecholamine stimulus
energy homeostasis
dendritic cell apoptotic process
positive regulation of monocyte aggregation
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
positive regulation of feeding behavior
positive regulation of dendritic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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