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Invitrogen
CD16-2 Monoclonal Antibody (AT137)
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Product Details
MA5-28254
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
AT137
Immunogen
Fusion Protein consisting of mouse CD16-2 and rat CD4
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
250 µg
Purification
Protein A
Storage buffer
TBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti human CD16-2 antibody, clone AT137, recognizes CD16-2, also known as FcRIV.
Target Information
FcgRIV, also known as CD16-2, is an intermediate-affinity activating receptor for IgG2a and IgG2b. CD16-2 is the mouse homolog of human FcgRIIIA. CD16-2 is a low-affinity IgE receptor for all allotypes and the ligation of FcgRIV by antigen-IgE immune complexes promotes macrophage-mediated phagocytosis and is involved in lung inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; FcgRIIIa; IgG Fc receptor III-A; low affinity immunoglobulin gamma Fc region receptor IV; unnamed protein product
Gene Aliases: 4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a; FcgRIV; Fcrl3
UniProt ID: (Mouse) A0A0B4J1G0
Entrez Gene ID: (Mouse) 246256
antibody-dependent cellular cytotoxicity
dendritic cell antigen processing and presentation
cell surface receptor signaling pathway
Fc-gamma receptor signaling pathway
Fc-epsilon receptor signaling pathway
neutrophil activation
natural killer cell degranulation
positive regulation of bone resorption
regulation of immune response
cellular response to lipopolysaccharide
Fc receptor-mediated immune complex endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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