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Invitrogen
CD13 Monoclonal Antibody (CVS19), PE
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Product Details
MA5-28281
Product Specifications
Species Reactivity
Horse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CVS19
Immunogen
Equine leucocytes
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS with 5% sucrose, 1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Horse CD13 antibody, clone CVS19 recognizes the equine CD13 cell surface antigen, also known as Aminopeptidase N, a single-pass type II membrane protein belonging to the peptidase N family with a molecular weight of between 150 - 170 kDa.
Reconstitute by adding 1 mL distilled water.
Target Information
CD13, also known as ANPEP, is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on a wide variety of cell types and tissues. It is prominently found on monocytes and granulocytes in the blood, but not on lymphocytes. Additionally, CD13 is expressed on endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, placenta, and myeloid leukemia cells. As a metalloprotease, CD13 preferentially catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides. It plays a crucial role in various biological processes, including the degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and the adhesion and migration of cells. CD13 is also involved in extracellular matrix degradation, signal transduction, inflammatory responses, regulation of intercellular contact, cell motility, and vascularization. In the context of disease, CD13 is associated with the protection of leukemic cells against apoptosis and is linked to a poor prognosis in carcinomas. Furthermore, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150); aminopeptidase N; h AP-N
Gene Aliases: CD13
Entrez Gene ID: (Horse) 100050397
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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