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Invitrogen
CD40 Monoclonal Antibody (IL-A156), FITC
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FIGURE: 1 / 1
CD40 Antibody (MA5-28364) in Flow
Flow cytometry of CD40 in red cell lysed bovine blood. Sample was incubated with CD40 monoclonal antibody (Product # MA5-28364) and gated on lymphocytes. Figures are arranged as follows: A) RPE conjugated mouse anti bovine CD32 and FITC conjugated mouse IgG1 isotype control. B) RPE conjugated mouse anti bovine CD32 and FITC conjugated mouse anti bovine CD40.
Product Details
MA5-28364
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
IL-A156
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Bovine CD40 antibody, clone IL-A156 recognizes the bovine CD40 cell surface antigen, which is expressed by B lymphocytes and a subset of T lymphocytes.
Target Information
CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction between CD40 and its ligand CD154 (gp39) on T cells is vital for T-B cell crosstalk, costimulation, and immune regulation. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction, while the AT-hook transcription factor AKNA is reported to regulate CD40 expression, which may be important for homotypic cell interactions. Additionally, the interaction between CD40 and its ligand is necessary for amyloid-beta-induced microglial activation, suggesting a role in the early pathogenesis of Alzheimer's disease. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been identified. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency, highlighting its importance in immune and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell surface antigen CD40; CD antigen CD40; CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; Immunoglobulin M; ImmunoglobulinM; MGC9013; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Gene Aliases: CD40; TNFRSF5
UniProt ID: (Bovine) Q28203
Entrez Gene ID: (Bovine) 286849
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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