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Invitrogen
HLA-DR Monoclonal Antibody (CC108)
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Product Details
MA5-28488
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CC108
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
250 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Bovine MHC class II DQ antibody, clone CC158 recognizes Bovine MHC Class II DQ. MHC Class II molecules are constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BoLA-DR-alpha; BoLA-DRB3.2; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DASS-397D15.1; DR beta-chain antigen binding domain; DR-beta chain MHC class II; FLJ51114; FLJ75017; FLJ76359; histocompatibility complex, class II, DR beta 3; leukocyte antigen DRB3; major histocompatibility complex class II DR-beta chain; major histocompatibility complex, class II, DR beta 3; MHC class II antigen beta chain; MHC class II antigen BoLA-DRB3; MHC class II DR beta chain; MHC class II DRB3; MHC class II leukocyte antigen BoLA-DRB3; MHC(BoLA) class II DR-beta chain; XXbac-BPG161M6.1
Gene Aliases: BLA-DRB3; BoLA-DRB; Bota-DRB01; Bota-DRB02; Bota-DRB04; Bota-DRB07; Bota-DRB21; Bota-DRB22; DRB3; LA-DRB
Entrez Gene ID: (Bovine) 506214, (Bovine) 282530, (Bovine) 613384
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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