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Invitrogen
C5AR1 Monoclonal Antibody (S5/1), PE
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FIGURE: 1 / 2
C5AR1 Antibody (MA5-28535) in Flow
Flow cytometry analysis (surface staining) of C5AR1 in human peripheral whole blood. Samples were stained with C5AR1 PE monoclonal antibody (Product # MA5-28535) using a dilution of 0.56 μg/mL. Separation of human neutrophil granulocytes (red-filled) from CD88 negative lymphocytes (black-dashed).
Product Details
MA5-28535
Product Specifications
Species Reactivity
Bovine,
Ferret,
Human,
Rabbit
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
S5/1
Immunogen
Human C5aR (Asp15-Asp27, N-terminal region)
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
Target Information
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphylatoxin C5a receptor; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5a-R; CD88; CD88 antigen; complement component 5a receptor 1
Gene Aliases: C5A; C5a-R; C5AR; C5AR1; C5R1; CD88
UniProt ID: (Human) P21730
Entrez Gene ID: (Bovine) 493645, (Rabbit) 100352978, (Human) 728
microglial cell activation
complement receptor mediated signaling pathway
regulation of immune system process
chemotaxis
inflammatory response
immune response
cellular defense response
cell communication
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
sensory perception of chemical stimulus
positive regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
signaling
neutrophil chemotaxis
response to peptidoglycan
complement component C5a signaling pathway
mRNA transcription from RNA polymerase II promoter
positive regulation of angiogenesis
astrocyte activation
positive regulation of epithelial cell proliferation
defense response to Gram-positive bacterium
cognition
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
beta-amyloid clearance
presynapse organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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