Search
Invitrogen
Drebrin Monoclonal Antibody (DBN-N-03)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 5
Drebrin Antibody (MA5-28543) in ICC/IF
Immunofluorescence analysis of Drebrin was performed using 70% confluent log phase HEK-293 cells. The cells were fixed with 4% Paraformaldehyde for 10 Minutes, permeabilized with 0.1% Triton™ X-100 for 10 Minutes, and blocked with 2% BSA for 10 Minutes at room temperature. The cells were labeled with Drebrin Monoclonal Antibody (DBN-N-03) (Product # MA5-28543) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488(Product ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-28543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
DBN-N-03
Immunogen
human drebrin (aa 1-326, N terminal)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 8
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.
It has also been successfully used in Mass Cytometry (CyTof).
Target Information
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: developmentally-regulated brain protein; DKFZp434D064; drebrin A; drebrin E; drebrin E2; F-actin binding protein; unnamed protein product
Gene Aliases: D0S117E
UniProt ID: (Human) Q16643, (Rat) Q07266, (Mouse) Q9QXS6
Entrez Gene ID: (Human) 1627, (Rat) 81653, (Mouse) 56320
actin filament organization
positive regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of dendrite development
positive regulation of dendritic spine morphogenesis
positive regulation of receptor localization to synapse
in utero embryonic development
spermatogenesis
nervous system development
response to xenobiotic stimulus
cell communication by chemical coupling
cell communication by electrical coupling
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
response to activity
regulation of actin filament polymerization
negative regulation of actin filament bundle assembly
maintenance of protein location in cell
positive regulation of axon extension
lung alveolus development
generation of neurons
neuron projection morphogenesis
regulation of filopodium assembly
prepulse inhibition
neural precursor cell proliferation
cellular response to tumor necrosis factor
cellular response to X-ray
cellular response to transforming growth factor beta stimulus
negative regulation of locomotion involved in locomotory behavior
modulation of inhibitory postsynaptic potential
postsynaptic actin cytoskeleton organization
positive regulation of substrate adhesion-dependent cell spreading
regulation of postsynaptic density protein 95 clustering
negative regulation of muscle filament sliding
positive regulation of excitatory postsynaptic potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support