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Invitrogen
CD89 Monoclonal Antibody (A59), PE
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Product Details
MA5-28547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
A59
Immunogen
Ag8.653 myeloma cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.045 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages. Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
Target Information
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD89; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; IgA Fc receptor Fc alpha Rla2 variant; immunoglobulin A Fc receptor; immunoglobulin A Fc receptor transcript variant deltaEC1 delta TM/C; Immunoglobulin alpha Fc receptor; unnamed protein product
Gene Aliases: CD89; CTB-61M7.2; FcalphaR; FcalphaRI; FCAR
UniProt ID: (Human) P24071
Entrez Gene ID: (Human) 2204, (Cynomolgus monkey) 102145896, (Rhesus monkey) 664734
neutrophil mediated immunity
immune response-regulating signaling pathway
immune response
positive regulation of neutrophil apoptotic process
cellular response to interferon-alpha
Fc receptor signaling pathway
neutrophil activation
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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