Search

  • Contáctenos
  • Orden Rápida

Invitrogen

Pan Cytokeratin Monoclonal Antibody (C-11), PE

View all (67) Cytokeratin Pan Type I/II antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

MA5-28574

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mammal, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

C-11

Immunogen

Keratin-enriched preparation from human epidermoid carcinoma cell line A431.

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745533

Product Specific Information

This antibody reacts with cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are members of intermediate filaments subfamily intracellular proteins represented in epithelial tissues.

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; 70 kd type II; cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-14; CK-15; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; cytokeratin endo A; cytokeratin endo B; cytokeratin-1; cytokeratin-10; cytokeratin-13; cytokeratin-14; cytokeratin-15; cytokeratin-16; cytokeratin-17; cytokeratin-18; cytokeratin-1B; cytokeratin-2e; cytokeratin-2P; cytokeratin-4; cytokeratin-5; cytokeratin-6A; cytokeratin-7; cytokeratin-8; cytoplasmic intermediate filament protein; cytoskeletal 57 kDa keratin; cytoskeletal protein; embryonic type II keratin 1; EndoA cytokeratin (5' end put.); putative; EndoA' cytokeratin (5' end put.); putative; epidermal keratin 10; epidermal keratin type I; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament; intermediate filament protein; intermediate filament protein K16; intermediate filament protein; K7; K1; K10; K13; K14; K15; K17; K18; K19; K1B; K2e; K2P; K6-alpha; K7; K76; K77; K8; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 14-like; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; keratin, type II cytoskeletal 6A; keratin-10; keratin-15, basic; keratin-15, beta; keratin-2 epidermis; keratin-2e; keratin-6-alpha; KRT1B; KRT5; mK6-alpha; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; Sak57; sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; type I keratin KA10; type I keratin KA13; type I keratin Ka14; type I keratin KA15; type I keratin KA16; type I keratin KA17; type I keratin KA19; type II cytoskeletal 1b; type II keratin Kb2; type II keratin Kb39; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; type-II intermediate filament protein; type-II keratin Kb1; type-II keratin Kb2; type-II keratin Kb3; Type-II Keratin Kb39; type-II keratin Kb4; type-II keratin Kb5; type-II keratin Kb6; type-II keratin Kb7; type-II keratin Kb8; type-II keratin Kb9; unnamed protein product

View more View less

Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AEI2; BCIE; BIE; CARD2; CK 2e; CK-14; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-4; CK-5; CK-6A; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6[a]; K6A; K6C; K6D; K7; K76; K77; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb9; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; Krt14; Krt14l; KRT16A; KRT1A; KRT1B; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT5A; KRT6C; KRT6D; Krt86; KRTE; MECD2; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC1; PC2; PC3; PCHC1; Sak57; SCL; Tfip8; TROMA-1; WSN1; WSN2

View more View less

UniProt ID: (Human) P04264, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Human) P05783, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Human) P05787, (Rat) Q6IMF3, (Mouse) P04104, (Mouse) P02535, (Rat) Q6IFW6, (Mouse) P08730, (Rat) Q6IFV4, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Rat) Q6IG02, (Mouse) Q3TTY5, (Rat) Q6IG00, (Mouse) P07744, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Rat) Q6IG12, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Rat) Q6IG01, (Mouse) Q6IFZ6, (Rat) Q10758, (Mouse) P11679

View more View less

Entrez Gene ID: (Human) 3848, (Human) 3858, (Human) 3860, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3872, (Human) 3875, (Human) 3880, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 51350, (Human) 374454, (Human) 3856, (Rat) 300250, (Mouse) 16678, (Mouse) 16661, (Rat) 450225, (Mouse) 16663, (Rat) 287699, (Mouse) 16664, (Rat) 287701, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Rat) 406228, (Mouse) 16681, (Rat) 315323, (Mouse) 16682, (Rat) 369017, (Mouse) 110308, (Rat) 120093743, (Mouse) 16687, (Rat) 300242, (Mouse) 110310, (Rat) 407757, (Mouse) 77055, (Rat) 406226, (Mouse) 406220, (Rat) 25626, (Mouse) 16691

View more View less

Function(s)
protein binding carbohydrate binding structural constituent of epidermis signaling receptor activity protein heterodimerization activity structural molecule activity structural constituent of cytoskeleton keratin filament binding scaffold protein binding RNA binding structural constituent of muscle cadherin binding involved in cell-cell adhesion macromolecular complex binding cytoskeletal protein binding
Process(es)
morphogenesis of an epithelium cytoskeleton organization epithelial cell differentiation regulation of translation in response to stress intermediate filament organization keratinization wound healing negative regulation of keratinocyte differentiation biological_process keratinocyte development epidermis development keratinocyte differentiation positive regulation of epidermis development protein heterotetramerization cornification cellular response to calcium ion tumor necrosis factor-mediated signaling pathway sarcomere organization response to hydrostatic pressure response to other organism epithelium development cell differentiation involved in embryonic placenta development extrinsic apoptotic signaling pathway hepatocyte apoptotic process negative regulation of hepatocyte apoptotic process tongue morphogenesis cellular response to retinoic acid Notch signaling pathway response to estrogen response to mechanical stimulus regulation of cell migration regulation of protein localization intermediate filament polymerization complement activation, lectin pathway negative regulation of inflammatory response establishment of skin barrier hair cycle intermediate filament bundle assembly positive regulation of keratinocyte differentiation positive regulation of cell growth hair follicle morphogenesis positive regulation of translation positive regulation of hair follicle development response to radiation positive regulation of cell proliferation cell differentiation negative regulation of cell migration killing of cells of other organism defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of entry of bacterium into host cell negative regulation of epithelial cell proliferation Wnt signaling pathway Golgi to plasma membrane protein transport negative regulation of apoptotic process intermediate filament cytoskeleton organization anatomical structure morphogenesis cell-cell adhesion pigmentation sebaceous gland development inflammatory response innate immune response keratinocyte migration keratinocyte activation keratinocyte proliferation intermediate filament-based process response to fructose response to nutrient levels hepatocyte differentiation mesenchymal stem cell differentiation cholangiocyte apoptotic process response to zinc ion response to ionizing radiation negative regulation of epithelial cell differentiation response to oxidative stress fibrinolysis regulation of angiogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support