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Invitrogen

Pan Cytokeratin Monoclonal Antibody (C-11), PE

View all (67) Cytokeratin Pan Type I/II antibodies

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Product Details

MA5-28574

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mammal, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

C-11

Immunogen

Keratin-enriched preparation from human epidermoid carcinoma cell line A431.

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745533

Product Specific Information

This antibody reacts with cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are members of intermediate filaments subfamily intracellular proteins represented in epithelial tissues.

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Bioinformatics

Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK 2e; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-8; Cytoskeletal 57 kDa keratin; cytoskeletal protein; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein; intermediate filament protein K16; intermediate filament protein; K7; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; Keratin-7; Keratin-76; Keratin-77; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt10 {ECO:0000250|UniProtKB:P13645}; krt13 {ECO:0000250|UniProtKB:P13646}; krt15 {ECO:0000250|UniProtKB:P19012}; krt17 {ECO:0000250|UniProtKB:Q04695}; krt18 {ECO:0000250|UniProtKB:P05783}; KRT1B; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; KRT5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; mK6-alpha; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; Type I keratin Ka10; Type I keratin Ka13; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka17; Type I keratin Ka19; type II cytoskeletal 1b; type II keratin Kb1; type II keratin Kb2; type II keratin Kb39; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; unnamed protein product

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Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AEI2; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb7; Kb9; Ker2; Kerd; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; MECD2; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; Sak57; SCL; Tfip8; WSN1; WSN2

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UniProt ID: (Human) P04264, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Human) P05783, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Human) P05787, (Rat) Q6IMF3, (Mouse) P04104, (Rat) Q6IFW6, (Mouse) P02535, (Mouse) P08730, (Rat) Q6IFV4, (Rat) Q6IFV1, (Mouse) Q61781, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Mouse) Q3TTY5, (Rat) Q6IG02, (Mouse) P07744, (Rat) Q6IG00, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Rat) Q6IG12, (Mouse) Q3UV17, (Rat) Q6IG01, (Mouse) Q6IFZ6, (Rat) Q10758, (Mouse) P11679

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Entrez Gene ID: (Human) 3848, (Human) 3858, (Human) 3860, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3872, (Human) 3875, (Human) 3880, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 51350, (Human) 374454, (Human) 3856, (Rat) 300250, (Mouse) 16678, (Rat) 450225, (Mouse) 16661, (Mouse) 16663, (Rat) 287699, (Rat) 287701, (Mouse) 16664, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Mouse) 16681, (Rat) 406228, (Mouse) 16682, (Rat) 315323, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Rat) 300242, (Rat) 407757, (Mouse) 77055, (Rat) 406226, (Mouse) 406220, (Rat) 25626, (Mouse) 16691

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Function(s)
protein binding carbohydrate binding structural constituent of epidermis signaling receptor activity protein heterodimerization activity structural molecule activity structural constituent of cytoskeleton keratin filament binding scaffold protein binding RNA binding cadherin binding involved in cell-cell adhesion structural constituent of muscle macromolecular complex binding cytoskeletal protein binding molecular_function MHC class II receptor activity MHC class II protein binding poly(A) RNA binding protein complex binding
Process(es)
morphogenesis of an epithelium signal transduction positive regulation of cell growth hair follicle morphogenesis keratinization intermediate filament organization positive regulation of translation positive regulation of hair follicle development cytoskeleton organization epithelial cell differentiation regulation of translation in response to stress aging response to zinc ion response to ionizing radiation hair cycle intermediate filament bundle assembly complement activation, lectin pathway retina homeostasis biological_process negative regulation of inflammatory response establishment of skin barrier keratinocyte differentiation cellular response to calcium ion tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process intermediate filament cytoskeleton organization extrinsic apoptotic signaling pathway hepatocyte apoptotic process epidermis development response to radiation stem cell differentiation Notch signaling pathway response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development positive regulation of cell proliferation cell differentiation killing of cells of other organism wound healing defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of entry of bacterium into host cell intermediate filament-based process anatomical structure morphogenesis Golgi to plasma membrane protein transport cell-cell adhesion mitophagy in response to mitochondrial depolarization inflammatory response negative regulation of cell migration innate immune response keratinocyte migration tongue morphogenesis cellular response to retinoic acid embryo development negative regulation of epithelial cell proliferation sebaceous gland development keratinocyte activation keratinocyte proliferation peptide cross-linking positive regulation of epidermis development protein heterotetramerization response to hydrostatic pressure response to other organism immune system process cell morphogenesis involved in differentiation multicellular organism development Wnt signaling pathway response to mechanical stimulus regulation of cell migration regulation of protein localization intermediate filament polymerization pigmentation response to oxidative stress fibrinolysis regulation of angiogenesis keratinocyte development
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