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Invitrogen
PCLO Monoclonal Antibody (PCLO-01), PE
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Product Details
MA5-28619
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
PCLO-01
Immunogen
Human recombinant PCLO protein
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes PCLO (Piccolo), a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytoplasmatic matrix of the neurons.
Target Information
The protein encoded by the PCLO gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aczonin; Protein piccolo; unnamed protein product
Gene Aliases: ACZ; KIAA0559; PCH3; PCLO
UniProt ID: (Human) Q9Y6V0
Entrez Gene ID: (Human) 27445
cytoskeleton organization
synaptic vesicle exocytosis
regulation of exocytosis
insulin secretion
protein localization to synapse
maintenance of presynaptic active zone structure
regulation of transport
regulation of biological quality
synaptic vesicle clustering
presynaptic actin cytoskeleton organization
presynapse organization
presynaptic active zone assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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