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Invitrogen

Bcl-xL Monoclonal Antibody (7B2.5), FITC

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Product Details

MA5-28637

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

3 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rhesus monkey, Rat

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

7B2.5

Immunogen

Recombinant human Bcl-xS

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Purification

purified

Storage buffer

PBS, pH 7.4

Contains

<0.1% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745596

Target Information

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl-2-like protein 1; bcl-xL; bcl-xS; Bcl2-L-1; BCLX; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3; unnamed protein product

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Gene Aliases: Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCL2L1; BCLX; Blc2l; EGK_02534; PPP1R52

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UniProt ID: (Human) Q07817, (Mouse) Q64373, (Rat) P53563

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Entrez Gene ID: (Human) 598, (Rhesus monkey) 713035, (Mouse) 12048, (Rat) 24888

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Function(s)
protein binding channel activity protein kinase binding identical protein binding BH3 domain binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity BH domain binding MDM2/MDM4 family protein binding
Process(es)
cytokinesis ovarian follicle development in utero embryonic development release of cytochrome c from mitochondria response to ischemia apoptotic process mitotic cell cycle checkpoint germ cell development spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to radiation fertilization response to virus suppression by virus of host apoptotic process response to cytokine growth regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process response to cycloheximide regulation of mitochondrial membrane permeability neuron apoptotic process regulation of mitochondrial membrane potential cellular process regulating host cell cycle in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of establishment of protein localization to plasma membrane negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process negative regulation of execution phase of apoptosis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of anoikis negative regulation of intrinsic apoptotic signaling pathway response to hypoxia endocytosis response to oxidative stress response to inorganic substance response to organonitrogen compound response to lead ion response to organic cyclic compound response to hydrogen peroxide response to peptide hormone response to electrical stimulus response to stress mitochondrion organization apoptotic mitochondrial changes negative regulation of autophagy regulation of cytokinesis positive regulation of mononuclear cell proliferation ectopic germ cell programmed cell death regulation of growth dendritic cell proliferation epithelial cell proliferation negative regulation of developmental process defense response to virus response to other organism transmembrane transport dendritic cell apoptotic process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of intracellular signal transduction negative regulation of protein localization to plasma membrane negative regulation of reproductive process negative regulation of dendritic cell apoptotic process regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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