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Invitrogen
CD107b (LAMP-2) Monoclonal Antibody (H4B4), PE-Cyanine5
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Product Details
MA5-28648
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
H4B4
Immunogen
Human adherent peripheral blood cells
Conjugate
Excitation/Emission Max
568/666 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.1, with proprietary stabilizer
Contains
<0.1% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon's disease).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD107 antigen-like family member B; CD107b; Igp96; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; LAMP-2C; LGP-96; Lysosome-associated membrane glycoprotein 2; RP23-193O17.2; unnamed protein product
Gene Aliases: CD107b; DND; EGK_20887; LAMP-2; LAMP2; LAMPB; LGP-96; LGP110
UniProt ID: (Human) P13473
Entrez Gene ID: (Rhesus monkey) 695379, (Human) 3920
protein targeting
autophagy
lysosomal lumen acidification
cellular response to starvation
protein import
protein catabolic process
negative regulation of protein complex assembly
regulation of protein stability
lysosomal lumen pH elevation
muscle cell cellular homeostasis
protein stabilization
chaperone-mediated autophagy
protein targeting to lysosome involved in chaperone-mediated autophagy
autophagosome maturation
negative regulation of NLRP3 inflammasome complex assembly
hydrogen ion transmembrane transport
lysosomal protein catabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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