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Invitrogen
beta-2 Microglobulin Monoclonal Antibody (F21-21), FITC
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Product Details
MA5-28737
Product Specifications
Species Reactivity
Avian,
Chicken
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
F21-21
Immunogen
Affinity purified chicken MHC-I molecules
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Amount
500 µg
Purification
purified
Storage buffer
PBS, pH 7.4, with proprietary stabilizer
Contains
<0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m
Gene Aliases: B2M; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03
UniProt ID: (Chicken) P21611
Entrez Gene ID: (Chicken) 414830
positive regulation of T cell mediated cytotoxicity
response to molecule of bacterial origin
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
positive regulation of T cell cytokine production
iron ion transport
immune response
learning or memory
negative regulation of neuron projection development
antigen processing and presentation of endogenous peptide antigen via MHC class I
T cell differentiation in thymus
regulation of iron ion transport
protein refolding
regulation of erythrocyte differentiation
positive regulation of receptor-mediated endocytosis
negative regulation of epithelial cell proliferation
protein homotetramerization
iron ion homeostasis
cellular response to iron(III) ion
cellular response to nicotine
modulation of age-related behavioral decline
negative regulation of receptor binding
positive regulation of ferrous iron binding
positive regulation of transferrin receptor binding
amyloid fibril formation
positive regulation of cellular senescence
negative regulation of forebrain neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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