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Invitrogen
Factor VII Recombinant Rabbit Monoclonal Antibody (121)
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Product Details
MA5-30572
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
121
Immunogen
Recombinant Mouse FVII protein (1-446).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse FVII/Factor VII/F7.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Factor 7; Factor7; serum prothrombin conversion accelerator; unnamed protein product
Gene Aliases: Cf7; FVII
UniProt ID: (Mouse) P70375
Entrez Gene ID: (Mouse) 14068
response to hypoxia
positive regulation of leukocyte chemotaxis
proteolysis
response to stress
blood coagulation
circadian rhythm
response to hormone
response to carbon dioxide
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
positive regulation of blood coagulation
organ regeneration
response to nutrient levels
positive regulation of TOR signaling
response to estradiol
response to vitamin K
response to genistein
response to estrogen
regulation of body fluid levels
positive regulation of positive chemotaxis
response to growth hormone
response to cholesterol
response to thyroid hormone
response to thyroxine
response to Thyroid stimulating hormone
response to 2,3,7,8-tetrachlorodibenzodioxine
response to astaxanthin
response to thyrotropin-releasing hormone
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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