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Invitrogen
Interferon alpha-2 Recombinant Rabbit Monoclonal Antibody (001)
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Product Details
MA5-30656
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
001
Immunogen
Recombinant Human Interferon alpha 2/IFNA2 Protein (Cys24-Glu188)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human Interferon alpha 2/IFNA2.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; cytokine; IFN-a; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFNA 2; IFNA2; IFNA2b; Interferon; interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha-2; Interferon alpha-A; interferon alpha-D; Interferon-alpha II; LeIF A; leIF D; RP11-354P17.2; unnamed protein product
Gene Aliases: IFN-alpha-2; IFN-alphaA; IFNA; IFNA2; IFNA2A; IFNA2B; IFNA2C; leIF A
UniProt ID: (Human) P01563
Entrez Gene ID: (Human) 3440
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
apoptotic process
defense response
inflammatory response
humoral immune response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
response to exogenous dsRNA
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
defense response to virus
type I interferon signaling pathway
receptor signaling pathway via STAT
cellular response to virus
negative regulation of T-helper 2 cell cytokine production
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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