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Invitrogen
MKP3 Recombinant Rabbit Monoclonal Antibody (SR39-09)
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Product Details
MA5-31988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SR39-09
Immunogen
Recombinant protein within Human DUSP6 aa 325-381.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6-ALT; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; serine/threonine specific protein phosphatase
Gene Aliases: 1300019I03Rik; DUSP6; HH19; MKP-3; MKP3; PYST1
UniProt ID: (Human) Q16828, (Rat) Q64346, (Mouse) Q9DBB1
Entrez Gene ID: (Human) 1848, (Rat) 116663, (Mouse) 67603
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
hydrolase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase tyrosine phosphatase activity
phosphatase activity
protein phosphatase
MAPK cascade
signal transduction
response to xenobiotic stimulus
cell differentiation
peptidyl-tyrosine dephosphorylation
positive regulation of apoptotic process
negative regulation of MAPK cascade
response to nitrosative stress
regulation of heart growth
ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
response to growth factor
inactivation of MAPK activity
negative regulation of protein phosphorylation
protein dephosphorylation
dorsal/ventral pattern formation
response to organic substance
positive regulation of cell death
response to organic cyclic compound
regulation of fibroblast growth factor receptor signaling pathway
response to drug
regulation of endodermal cell fate specification
dephosphorylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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