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Invitrogen
Lamin A/C Recombinant Rabbit Monoclonal Antibody (JE51-60)
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FIGURE: 1 / 10
Lamin A/C Antibody (MA5-34874) in ICC/IF
Immunofluorescent analysis of Lamin A/C in SiHa cells (green). Samples were formalin fixed, permeabilized with 0.1% Triton X-100 in TBS (1 hour, room temperature) and blocked with 1% BSA (15 min, room temperature), incubated with Lamin A/C monoclonal antibody (Product # MA5-34874) at a dilution of 1:100 (1 hour, room temperature), and followed by Alexa Fluor 488 Goat anti-Rabbit IgG and DAPI (blue) with a d... View More
Product Details
MA5-34874
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE51-60
Immunogen
Recombinant protein within Human Lamin A/C aa 191-309.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: A549 cell, A431, SiHa, rat testis tissue, human tonsil tissue, human colon carcinoma tissue, human breast tissue, human gastric carcinoma tissue, mouse brain tissue, Hela.
Target Information
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa lamin; epididymis secretory sperm binding protein; lamin A protein; Lamin A+C mutant; lamin a-c; lamin A/C; lamin A/C-like 1; Lamin AC; lamin C; lamin C protein; mandibuloacral dysplasia type A; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; MADA; PRO1
UniProt ID: (Human) P02545
Entrez Gene ID: (Human) 4000
protein import into nucleus
nucleus organization
nuclear envelope organization
nuclear migration
muscle organ development
protein localization
negative regulation of cell proliferation
positive regulation of gene expression
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
protein localization to nucleus
nuclear pore localization
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
negative regulation of release of cytochrome c from mitochondria
cellular senescence
protein localization to nuclear envelope
regulation of protein localization to nucleus
negative regulation of cardiac muscle hypertrophy in response to stress
DNA double-strand break attachment to nuclear envelope
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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