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Phospho-Stat6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (Stat6Y641-G12), APC
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FIGURE: 1 / 1
Phospho-Stat6 (Tyr641) Antibody (MA5-36910) in Flow
Flow cytometry of Phospho-Stat6 (Tyr641) using U937 cells. Samples were incubated in monoclonal Phospho-Stat6 (Tyr641) antibody (Product # MA5-36910). Images correspond with the following conditions: negative control (blue), stained and untreated (red), treated with IFNa and IL-4 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-36910
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Stat6Y641-G12
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6.
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12S1644; IL4 STAT; LITAF binding protein; Mutations: 16:OK; signal transducer and activator of transcription 6, interleukin-4 induced; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT; unnamed protein product
Gene Aliases: D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C
UniProt ID: (Human) P42226, (Mouse) P52633
Entrez Gene ID: (Human) 6778, (Mouse) 20852
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein phosphatase binding
identical protein binding
sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
JAK-STAT cascade
gene expression
cytokine-mediated signaling pathway
interleukin-4-mediated signaling pathway
regulation of cell proliferation
response to peptide hormone
positive regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of cold-induced thermogenesis
negative regulation of transcription from RNA polymerase II promoter
T-helper 1 cell lineage commitment
positive regulation of lymphocyte mediated immunity
negative regulation of type 2 immune response
positive regulation of gene expression
T cell differentiation
mammary gland development
mammary gland epithelial cell proliferation
response to cytokine
positive regulation of isotype switching to IgE isotypes
positive regulation of immune response
positive regulation of B cell activation
mammary gland morphogenesis
cellular response to hydrogen peroxide
cellular response to reactive nitrogen species
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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