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Invitrogen
Phospho-4EBP1 (Thr37, Thr46) Recombinant Rabbit Monoclonal Antibody (4EB1T37T46-A5)
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FIGURE: 1 / 6
Phospho-4EBP1 (Thr37, Thr46) Antibody (MA5-36935) in IHC
Flow cytometry of Phospho-EIF4EBP1 (Thr37, Thr46) using rat kidney cells. Samples were incubated in monoclonal Phospho-EIF4EBP1 (Thr37, Thr46) antibody (Product # MA5-36935). Images correspond with the following conditions: punctate in the nuclei (red), control peptide (A) nor non-phospho 4E-BP1 peptide (B) phospho-peptide signal (C), negative control (D).
Product Details
MA5-36935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4EB1T37T46-A5
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr37/46 of human phospho 4E-BP1.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4E-BP1; eIF4E-binding protein 1; EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; unnamed protein product
Gene Aliases: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
regulation of translation
negative regulation of translation
TOR signaling
positive regulation of mitotic cell cycle
negative regulation of translational initiation
IRES-dependent translational initiation
regulation of translational initiation
insulin receptor signaling pathway
negative regulation of protein complex assembly
response to ischemia
lung development
response to ethanol
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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