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Invitrogen
Phospho-Shp2 (Tyr580) Recombinant Rabbit Monoclonal Antibody (Shp2Y580-4A2)
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FIGURE: 1 / 3
Phospho-Shp2 (Tyr580) Antibody (MA5-36977) in Flow
Flow cytometry of Phospho-Shp2 (Tyr580) using THP1 cells. Samples were incubated in monoclonal Phospho-Shp2 (Tyr580) antibody (Product # MA5-36977) with a dilution of 0.1 µg/mL. Images correspond with the following conditions: negative control (light blue), untreated (red), treated with IFNa/IL-4/pervanadate (green), untreated and blocked with phospho-peptide (black), treated and blocked with phospho peptid... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-36977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Shp2Y580-4A2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2SH2 domain protein; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP1C; SH2 domain-containing protein tyrosine phosphatase 2; SH2 domain-containing protein tyrosine phosphatase-2; unnamed protein product
Gene Aliases: 2700084A17Rik; BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; SHP2; Syp
UniProt ID: (Human) Q06124, (Mouse) P35235
Entrez Gene ID: (Human) 5781, (Mouse) 19247
phosphotyrosine binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
protein kinase binding
receptor signaling complex scaffold activity
receptor tyrosine kinase binding
cadherin binding
cell adhesion molecule binding
peptide hormone receptor binding
binding, bridging
protein tyrosine kinase binding
protein domain specific binding
D1 dopamine receptor binding
phospholipase binding
insulin receptor substrate binding
epidermal growth factor receptor signaling pathway
brain development
heart development
fibroblast growth factor receptor signaling pathway
cytokine-mediated signaling pathway
T cell costimulation
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of chondrocyte differentiation
negative regulation of type I interferon production
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
negative regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
atrioventricular canal development
ERBB signaling pathway
negative regulation of T cell proliferation
vasodilation
regulation of protein complex assembly
positive regulation of ossification
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
genitalia development
inner ear development
negative regulation of antigen receptor-mediated signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
positive regulation of protein kinase B signaling
face morphogenesis
regulation of type I interferon-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to epidermal growth factor stimulus
positive regulation of intracellular signal transduction
negative regulation of neutrophil activation
DNA damage checkpoint
protein dephosphorylation
lipid metabolic process
triglyceride metabolic process
integrin-mediated signaling pathway
axonogenesis
hormone-mediated signaling pathway
positive regulation of signal transduction
cerebellar cortex formation
platelet formation
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
microvillus organization
regulation of tumor necrosis factor production
regulation of cell adhesion mediated by integrin
multicellular organism growth
organ growth
megakaryocyte development
hormone metabolic process
glucose homeostasis
regulation of MAPK cascade
positive regulation of mitotic cell cycle
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
positive regulation of focal adhesion assembly
Bergmann glial cell differentiation
negative regulation of growth hormone secretion
intestinal epithelial cell migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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