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Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

1 Published Figure
2 References
View all (62) CREB antibodies

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Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

Product Details

MA5-36992

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

CREBS133-4D11

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB.
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896927

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer's Disease, histiocytoma and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: active transcription factor CREB; active transcription factor CREB-A; active transcription factor CREB-B; cAMP-response element-binding protein-1; CREB1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP response element-binding protein-1 alpha isoform; delta CREB; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; unnamed protein product

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Gene Aliases: 2310001E10Rik; 3526402H21Rik; CREB; CREB-1

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UniProt ID: (Human) P16220, (Mouse) Q01147

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Entrez Gene ID: (Human) 1385, (Mouse) 12912

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding enzyme binding Hsp70 protein binding histone acetyltransferase binding cAMP response element binding identical protein binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding arrestin family protein binding sequence-specific double-stranded DNA binding double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation transforming growth factor beta receptor signaling pathway axonogenesis lactation memory circadian rhythm regulation of cell size visual learning response to xenobiotic stimulus gene expression negative regulation of gene expression response to purine-containing compound response to activity pituitary gland development cell differentiation mammary gland development positive regulation of transforming growth factor beta3 production secretory granule organization response to glucagon chemotaxis to arachidonic acid response to nicotine cellular response to hepatocyte growth factor stimulus response to erythropoietin cellular response to platelet-derived growth factor stimulus positive regulation of multicellular organism growth response to cocaine mRNA transcription from RNA polymerase II promoter regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process response to morphine response to ethanol positive regulation of fat cell differentiation positive regulation of osteoclast differentiation positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion positive regulation of lipid biosynthetic process regulation of fibroblast proliferation protein stabilization positive regulation of cardiac muscle tissue development regulation of glial cell proliferation lung epithelium development lung saccule development Type I pneumocyte differentiation cellular response to zinc ion cellular response to retinoic acid cellular response to growth factor stimulus cellular response to fatty acid cellular response to transforming growth factor beta stimulus inhibition of non-skeletal tissue mineralization cAMP/PKA signal transduction positive regulation of long-term synaptic potentiation response to L-glutamate response to dehydroepiandrosterone positive regulation of membrane depolarization cellular response to forskolin cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus cellular response to leukemia inhibitory factor response to hypobaric hypoxia regulation of testosterone biosynthetic process signal transduction
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