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Invitrogen
Phospho-SLP76 (Tyr128) Recombinant Rabbit Monoclonal Antibody (SLP76Y128-3F8), PE
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FIGURE: 1 / 1
Phospho-SLP76 (Tyr128) Antibody (MA5-36998) in Flow
Flow cytometry of Phospho-SLP76 (Tyr128) using Ramos cells. Samples were incubated in monoclonal Phospho-SLP76 (Tyr128) antibody (Product # MA5-36998). Images correspond with the following conditions: negative control (blue), untreated (red), treated with pervanadate (green).
Product Details
MA5-36998
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SLP76Y128-3F8
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 76 kDa tyrosine phosphoprotein; Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; unnamed protein product
Gene Aliases: AI323664; BB161688; IMD81; LCP2; SLP-76; SLP76; twm
UniProt ID: (Human) Q13094, (Mouse) Q60787
Entrez Gene ID: (Human) 3937, (Mouse) 16822
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