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Phospho-KSR1 (Ser392) Recombinant Rabbit Monoclonal Antibody (KSR1S392-3A4), PE
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FIGURE: 1 / 1
Phospho-KSR1 (Ser392) Antibody (MA5-37017) in Flow
Flow cytometry of Phospho-KSR1 (Ser392) using HeLa human adenocarcinoma cells. Samples were incubated in monoclonal Phospho-KSR1 (Ser392) antibody (Product # MA5-37017). Images correspond with the following conditions: untreated, unstained negative control (blue), treated with lambda phosphatase and stained (red), untreated and stained (green).
Product Details
MA5-37017
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
KSR1S392-3A4
Immunogen
A synthetic phosphor-peptide corresponding to residues surrounding Ser392 of human phospho KSR1.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP kinase; HB protein; kinase KSR1; Kinase suppressor of Ras 1; mKSR1; OTTHUMP00000162931; Protein Hb; protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author.; unnamed protein product
Gene Aliases: AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; KSR; KSR1; RSU2
UniProt ID: (Human) Q8IVT5, (Mouse) Q61097
Entrez Gene ID: (Human) 8844, (Mouse) 16706
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP-kinase scaffold activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
metal ion binding
14-3-3 protein binding
protein serine kinase activity
protein C-terminus binding
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase binding
non-receptor serine/threonine protein kinase
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