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Invitrogen
Phospho-RelB (Ser552) Recombinant Rabbit Monoclonal Antibody (RelBS552-A7)
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FIGURE: 1 / 3
Phospho-RelB (Ser552) Antibody (MA5-37030) in Flow
Flow cytometry of Phospho-RelB (Ser552) using 3T3 cells. Samples were incubated in monoclonal Phospho-RelB (Ser552) antibody (Product # MA5-37030) with a dilution of 0.01 µg/mL. Images correspond with the following conditions: isotype antibody-stained negative control (light blue), untreated (red), treated with UV and PMA (green).
Product Details
MA5-37030
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RelBS552-A7
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser552 of human phospho RelB.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The NFkB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNAbinding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFkB subunit. Rel B does not bind with high affinity to NFkB sites, but heterodimers between Rel B and p50 bind with an affinity comparable to that of p50 NFkB homodimers. However, Rel B/p50 heterodimers, in contrast to NFkB heterodimers, transactivates transcription of promotors containing kB binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: I-Rel; OTTHUMP00000221313; rel b; Transcription factor RelB; unnamed protein product; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); v-rel reticuloen; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene Aliases: I-REL; IMD53; IREL; REL-B; RELB; shep
UniProt ID: (Human) Q01201, (Mouse) Q04863
Entrez Gene ID: (Human) 5971, (Mouse) 19698
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
identical protein binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
Rel homology transcription factor
regulation of transcription, DNA-templated
inflammatory response
I-kappaB kinase/NF-kappaB signaling
regulation of gene expression
negative regulation of macromolecule biosynthetic process
antigen processing and presentation
lymphocyte differentiation
negative regulation of interferon-beta production
circadian regulation of gene expression
response to cytokine
NIK/NF-kappaB signaling
T-helper 1 type immune response
myeloid dendritic cell differentiation
T-helper 1 cell differentiation
innate immune response
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
cellular response to osmotic stress
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of gene expression
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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