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Invitrogen

Phospho-MEK1 (Ser298) Recombinant Rabbit Monoclonal Antibody (MEK1S298-H8)

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Phospho-MEK1 (Ser298) Recombinant Rabbit Monoclonal Antibody (MEK1S298-H8)

Product Details

MA5-37069

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Flow Cytometry (Flow)

1-1,000 ng/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MEK1S298-H8

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser298 of human phospho MEK1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

10 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897004

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK2; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

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Gene Aliases: CFC3; MAPKK1; MEK1; MEL; MKK1; PRKMK1

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UniProt ID: (Human) Q02750, (Rat) Q01986

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Entrez Gene ID: (Human) 5604, (Rat) 170851

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Function(s)
protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity
Process(es)
MAPK cascade regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction neuromuscular junction development negative regulation of cell proliferation positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression Schwann cell development neuron differentiation positive regulation of cell migration melanosome transport regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion ERBB signaling pathway ERBB2-ERBB3 signaling pathway myelination positive regulation of MAPK cascade positive regulation of transcription, DNA-templated positive regulation of muscle contraction vesicle transport along microtubule insulin-like growth factor receptor signaling pathway Golgi inheritance response to axon injury neuron projection morphogenesis response to glucocorticoid triglyceride homeostasis ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of early endosome to late endosome transport positive regulation of ATP biosynthetic process protein phosphorylation heart development insulin receptor signaling pathway cerebellar cortex formation keratinocyte differentiation thyroid gland development intracellular signal transduction positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of Ras protein signal transduction thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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