Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Phospho-MEK1/MEK2 (Ser221) Recombinant Rabbit Monoclonal Antibody (MEK12S221-D3), FITC

View all (38) MEK1/2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-MEK1/MEK2 (Ser221) Recombinant Rabbit Monoclonal Antibody (MEK12S221-D3), FITC

Product Details

MA5-37078

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MEK12S221-D3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser221 of human phospho MEK1/2.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897013

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; mitogen-activated protein kinase kinase 2, p45; MP2K1; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

View more View less

Gene Aliases: CFC3; CFC4; MAPKK1; MAPKK2; MEK1; MEK2; MEKK1; MEL; MK2; MKK1; MKK2; PRKMK1; PRKMK2

View more View less

UniProt ID: (Human) Q02750, (Human) P36507, (Mouse) P31938, (Mouse) Q63932

View more View less

Entrez Gene ID: (Human) 5604, (Human) 5605, (Mouse) 26395, (Mouse) 26396

View more View less

Function(s)
protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity PDZ domain binding binding, bridging
Process(es)
MAPK cascade positive regulation of gene expression regulation of stress-activated MAPK cascade peptidyl-serine autophosphorylation positive regulation of transcription, DNA-templated ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance regulation of early endosome to late endosome transport regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction neuromuscular junction development negative regulation of cell proliferation positive regulation of autophagy negative regulation of gene expression Schwann cell development neuron differentiation positive regulation of cell migration melanosome transport positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion ERBB signaling pathway ERBB2-ERBB3 signaling pathway myelination positive regulation of MAPK cascade positive regulation of muscle contraction vesicle transport along microtubule insulin-like growth factor receptor signaling pathway Golgi inheritance response to axon injury neuron projection morphogenesis response to glucocorticoid triglyceride homeostasis regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway positive regulation of ATP biosynthetic process protein phosphorylation heart development insulin receptor signaling pathway cerebellar cortex formation keratinocyte differentiation thyroid gland development positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of Ras protein signal transduction thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development response to ischemia peptidyl-tyrosine phosphorylation positive regulation of cell motility
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support