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Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), FITC

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Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), FITC

Product Details

MA5-37094

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

LckY505-A3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr505 of human phospho Lck.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897028

Target Information

LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.10.2; kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; OTTHUMP00000008640; OTTHUMP00000008740; OTTHUMP00000008741; p56(LSTRA) protein-tyrosine kinase; p56-LCK; Protein YT16; Proto-oncogene Lck; proto-oncogene tyrosine-protein kinase LCK; RP4-675E8.4; T cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; tyr; Tyrosine-protein kinase Lck; unnamed protein product

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Gene Aliases: IMD22; LCK; LSK; p56lck; pp58lck; YT16

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UniProt ID: (Human) P06239

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Entrez Gene ID: (Human) 3932

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Function(s)
nucleotide binding phosphotyrosine binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein serine/threonine phosphatase activity receptor binding protein binding ATP binding phospholipase activator activity kinase activity transferase activity protein kinase binding protein phosphatase binding SH2 domain binding T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding phospholipase binding phosphatidylinositol 3-kinase binding ATPase binding protein antigen binding
Process(es)
immune response-activating cell surface receptor signaling pathway protein phosphorylation cellular zinc ion homeostasis cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway response to xenobiotic stimulus positive regulation of gene expression peptidyl-tyrosine phosphorylation hemopoiesis platelet activation T cell differentiation T cell costimulation positive regulation of heterotypic cell-cell adhesion intracellular signal transduction peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway T cell activation gamma-delta T cell differentiation positive regulation of MAPK cascade positive regulation of gamma-delta T cell differentiation regulation of regulatory T cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of T cell activation leukocyte migration release of sequestered calcium ion into cytosol positive regulation of multicellular organismal process regulation of lymphocyte activation CD27 signaling pathway positive regulation of leukocyte cell-cell adhesion positive regulation of intrinsic apoptotic signaling pathway
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