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Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1), PE
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FIGURE: 1 / 1
Phospho-c-Cbl (Tyr700) Antibody (MA5-37106) in Flow
Flow cytometry of Phospho-c-Cbl (Tyr700) using C6 cells. Samples were incubated in monoclonal Phospho-c-Cbl (Tyr700) antibody (Product # MA5-37106). Images correspond with the following conditions: cell only negative control (blue), treated with imatinib (red), with pervanadate (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37106
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CblY700-E1
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr700 of human phospho c-Cbl.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin protein ligase; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; proto-oncogene c-CBL; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; signal transduction protein CBL; unnamed protein product
Gene Aliases: 4732447J05Rik; C-CBL; cbl; Cbl-2; CBL2; FRA11B; NSLL; RGD1561386; RNF55
UniProt ID: (Human) P22681, (Mouse) P22682
Entrez Gene ID: (Human) 867, (Rat) 500985, (Mouse) 12402
phosphotyrosine binding
ubiquitin-protein transferase activity
calcium ion binding
protein binding
SH3 domain binding
protein kinase binding
receptor tyrosine kinase binding
phosphatidylinositol 3-kinase regulatory subunit binding
cadherin binding
metal ion binding
ephrin receptor binding
ubiquitin protein ligase activity
protein tyrosine kinase binding
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
signal transduction
cell surface receptor signaling pathway
male gonad development
response to gamma radiation
response to activity
protein ubiquitination
regulation of signaling
regulation of Rap protein signal transduction
response to testosterone
cellular response to platelet-derived growth factor stimulus
negative regulation of epidermal growth factor receptor signaling pathway
response to starvation
negative regulation of apoptotic process
mast cell degranulation
response to ethanol
positive regulation of receptor-mediated endocytosis
protein stabilization
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
protein autoubiquitination
positive regulation of protein kinase B signaling
ubiquitin-dependent endocytosis
protein K63-linked ubiquitination
cellular response to hypoxia
cellular response to nerve growth factor stimulus
regulation of platelet-derived growth factor receptor-alpha signaling pathway
protein phosphorylation
bone resorption
cytokine-mediated signaling pathway
positive regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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