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Phospho-PLK1 (Thr210) Recombinant Rabbit Monoclonal Antibody (PLK1T210-C2), APC
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FIGURE: 1 / 1
Phospho-PLK1 (Thr210) Antibody (MA5-37127) in Flow
Flow cytometry of Phospho-PLK1 (Thr210) using HeLa cells. Samples were incubated in monoclonal Phospho-PLK1 (Thr210) antibody (Product # MA5-37127). Images correspond with the following conditions: untreated, unstained negative control (blue), untreated and stained (red), treated with nocodazole and stained (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37127
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PLK1T210-C2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1.
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell cycle regulated protein kinase; PLK 1; PLK-1; polo (Drosophia)-like kinase; polo-like kinase; serine/threonine-protein kinase 13; STPK14; unnamed protein product
Gene Aliases: PLK; STPK13
UniProt ID: (Human) P53350
Entrez Gene ID: (Human) 5347
mitotic sister chromatid segregation
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mitotic cell cycle
nuclear division
mitotic cytokinesis
microtubule bundle formation
double-strand break repair
protein phosphorylation
mitotic spindle organization
sister chromatid cohesion
mitotic chromosome condensation
mitotic nuclear envelope disassembly
metaphase/anaphase transition of mitotic cell cycle
mitotic spindle assembly checkpoint
mitotic G2 DNA damage checkpoint
centrosome cycle
regulation of mitotic cell cycle
regulation of cell cycle process
regulation of mitotic metaphase/anaphase transition
astral microtubule organization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
negative regulation of apoptotic process
establishment of protein localization
positive regulation of mitotic metaphase/anaphase transition
Golgi inheritance
regulation of cell cycle
protein localization to chromatin
double-strand break repair via alternative nonhomologous end joining
positive regulation of protein localization to nucleus
regulation of mitotic spindle assembly
regulation of mitotic cell cycle phase transition
mitotic cleavage furrow formation
regulation of protein localization to cell cortex
positive regulation of mitotic nuclear envelope disassembly
regulation of anaphase-promoting complex-dependent catabolic process
negative regulation of double-strand break repair via homologous recombination
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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