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Phospho-HSP27 (Ser82) Recombinant Rabbit Monoclonal Antibody (HSP27S82-CB2), APC
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FIGURE: 1 / 1
Phospho-HSP27 (Ser82) Antibody (MA5-37151) in Flow
Flow cytometry of Phospho-HSP27 (Ser82) using HeLa cells. Samples were incubated in monoclonal Phospho-HSP27 (Ser82) antibody (Product # MA5-37151) with a dilution of 0.05 µg/mL. Images correspond with the following conditions: unstained, negative control (blue), untreated (red), treated with UV and TPA (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37151
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HSP27S82-CB2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser82 of human phospho Hsp27.
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 27-kda heat shock protein; 28 kDa heat shock protein; DKFZp586P1322; epididymis secretory protein Li 102; estrogen-regulated 24 kDa protein; growth-related 25 kDa protein; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; heat shock protein 1; heat shock protein family B member 1; heat shock protein, 25 kDa; HS; HSP; HSP 25; HSP 27; HSP27; HSPB1; p25; Phospho-HSP 27; stress-responsive protein 27; unnamed protein product
Gene Aliases: 27kDa; CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067; Hsp25; HSP27; HSP28; SRP27
UniProt ID: (Human) P04792, (Mouse) P14602
Entrez Gene ID: (Human) 3315, (Mouse) 15507
RNA binding
protein kinase C binding
protein binding
protein kinase C inhibitor activity
protein kinase binding
identical protein binding
protein homodimerization activity
ubiquitin binding
protein binding involved in protein folding
RNA polymerase II sequence-specific DNA binding transcription factor binding
regulation of protein phosphorylation
regulation of translational initiation
protein folding
response to unfolded protein
response to heat
response to virus
regulation of autophagy
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
protein refolding
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
vascular endothelial growth factor receptor signaling pathway
protein stabilization
intestinal epithelial structure maintenance
platelet aggregation
negative regulation of protein kinase C signaling
anterograde axonal protein transport
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of endothelial cell chemotaxis
positive regulation of neuron projection development
negative regulation of regulatory T cell differentiation
negative regulation of cellular response to oxidative stress
negative regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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