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Phospho-MCM2 (Ser139) Recombinant Rabbit Monoclonal Antibody (MCM2S139-B12), FITC
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FIGURE: 1 / 1
Phospho-MCM2 (Ser139) Antibody (MA5-37179) in Flow
Flow cytometry of Phospho-MCM2 (Ser139) using C6 cells. Samples were incubated in monoclonal Phospho-MCM2 (Ser139) antibody (Product # MA5-37179). Images correspond with the following conditions: untreated, unstained negative control (blue), untreated (red), treated with staurosporine (green).
Product Details
MA5-37179
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MCM2S139-B12
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho MCM2.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. MCM2 has been mapped to 3q21. From its localization, CDCL1 became a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell devision cycle-like 1; cyclin-like 1; DNA replication licensing factor MCM2; KIAA0030; MGC10606; mini chromosome maintenance deficient 2; minichromosome maintenance deficient 2 (mitotin); minichromosome maintenance deficient 2 mitotin; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28; unnamed protein product
Gene Aliases: AA959861; AW476101; BM28; CCNL1; cdc19; CDCL1; D3S3194; DFNA70; KIAA0030; MCM2; Mcmd2; MITOTIN; mKIAA0030
UniProt ID: (Human) P49736, (Mouse) P97310
Entrez Gene ID: (Human) 4171, (Rat) 312538, (Mouse) 17216
nucleotide binding
DNA binding
DNA helicase activity
DNA replication origin binding
single-stranded DNA binding
helicase activity
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
histone binding
3'-5' DNA helicase activity
metal ion binding
DNA metabolism protein
double-strand break repair via break-induced replication
DNA replication
DNA replication initiation
nucleosome assembly
apoptotic process
regulation of DNA-dependent DNA replication initiation
cellular response to interleukin-4
cochlea development
mitotic DNA replication initiation
DNA unwinding involved in DNA replication
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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