Search
Invitrogen
Phospho-Lamin A/C (Ser22) Recombinant Rabbit Monoclonal Antibody (LaminACS22-CF12), PE
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
Phospho-Lamin A/C (Ser22) Antibody (MA5-37182) in Flow
Flow cytometry of Phospho-Lamin A/C (Ser22) using HeLa cells. Samples were incubated in monoclonal Phospho-Lamin A/C (Ser22) antibody (Product # MA5-37182). Images correspond with the following conditions: untreated (black), treated with nocodazole (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37182
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
LaminACS22-CF12
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser22 of human phospho Lamin A/C.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 70 kDa lamin; epididymis secretory sperm binding protein; lamin A protein; Lamin A+C mutant; lamin a-c; lamin A/C; lamin A/C-like 1; Lamin AC; lamin C; lamin C protein; lamin-A/C; mandibuloacral dysplasia type A; mutant 453W; Mutant lamin A/C; nuclear envelope protein; prelamin-A/C; progerin; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1
UniProt ID: (Human) P02545, (Mouse) P48678
Entrez Gene ID: (Human) 4000, (Mouse) 16905
double-strand break repair via nonhomologous end joining
protein import into nucleus
nucleus organization
nuclear envelope organization
nuclear migration
muscle organ development
protein localization
negative regulation of cell proliferation
positive regulation of gene expression
establishment of cell polarity
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
protein localization to nucleus
positive regulation of osteoblast differentiation
nuclear pore localization
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
negative regulation of release of cytochrome c from mitochondria
cellular senescence
protein localization to nuclear envelope
regulation of protein localization to nucleus
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of adipose tissue development
DNA double-strand break attachment to nuclear envelope
negative regulation of extrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support