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Invitrogen
Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), FITC
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Product Details
MA5-37194
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PKCgT514-PF4
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr514 of human phospho PKC gamma.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PKC gamma; PKC-gamma; Protein kinase C gamma type; protein kinase C type I (gamma type); unnamed protein product
Gene Aliases: PKC; PKC-gamma; PKCC; PKCG; PKCgamma; PKCI; PKCI(3); Prkc; Prkcc; PRKCG; RATPKCI; SCA14
UniProt ID: (Human) P05129, (Mouse) P63318, (Rat) P63319
Entrez Gene ID: (Human) 5582, (Mouse) 18752, (Rat) 24681
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
phospholipase C-activating G-protein coupled receptor signaling pathway
chemical synaptic transmission
learning or memory
chemosensory behavior
response to toxic substance
negative regulation of protein ubiquitination
regulation of response to food
positive regulation of mismatch repair
intracellular signal transduction
negative regulation of protein catabolic process
regulation of circadian rhythm
response to morphine
negative regulation of neuron apoptotic process
response to pain
rhythmic process
regulation of phagocytosis
long-term synaptic potentiation
innervation
presynaptic modulation of chemical synaptic transmission
synaptic signaling via neuropeptide
negative regulation of proteasomal protein catabolic process
response to angiotensin
response to psychosocial stress
regulation of synaptic vesicle exocytosis
protein phosphorylation
phosphorylation
protein autophosphorylation
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