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Invitrogen
Phospho-Jak1 (Tyr1034, Tyr1035) Recombinant Rabbit Monoclonal Antibody (Jak1Y10341035-F11), APC
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FIGURE: 1 / 1
Phospho-Jak1 (Tyr1034, Tyr1035) Antibody (MA5-37416) in Flow
Flow cytometry of Phospho-Jak1 (Tyr1034, Tyr1035) using Jurkat cells. Samples were incubated in monoclonal Phospho-Jak1 (Tyr1034, Tyr1035) antibody (Product # MA5-37416). Images correspond with the following conditions: untreated, unstained negative control (blue), untreated (red), treated with IFNa/IL-4/pervanadate (green).
Product Details
MA5-37416
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Jak1Y10341035-F11
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr1034/1035 of human phospho-Jak1.
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.10.2; JAK-1; Janus kinase 1; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Aliases: AA960307; AIIDE; BAP004; C130039L05Rik; JAK1; JAK1A; JAK1B; JTK3
UniProt ID: (Human) P23458
Entrez Gene ID: (Human) 3716, (Mouse) 16451
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
ubiquitin protein ligase binding
CCR5 chemokine receptor binding
metal ion binding
transferase activity, transferring phosphorus-containing groups
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
JAK-STAT cascade
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
positive regulation of homotypic cell-cell adhesion
intracellular signal transduction
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
interleukin-11-mediated signaling pathway
type III interferon-mediated signaling pathway
response to antibiotic
regulation of multicellular organismal process
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
cellular response to virus
cellular response to interleukin-7
interleukin-10-mediated signaling pathway
protein localization to cell-cell junction
positive regulation of protein localization to nucleus
positive regulation of sprouting angiogenesis
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
protein autophosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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