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Invitrogen
MC1R Monoclonal Antibody (578CT6.2.3)
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Product Details
MA5-37591
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
578CT6.2.3
Immunogen
KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
400 µg
Purification
Euglobulin precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha melanocyte stimulating hormone receptor; MC1 receptor; MC1-R; Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; unnamed protein product
Gene Aliases: CMM5; MC1R; MSH-R; MSHR; SHEP2
UniProt ID: (Human) Q01726
Entrez Gene ID: (Human) 4157
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
UV protection
regulation of gene expression
sensory perception of pain
negative regulation of tumor necrosis factor production
intracellular signal transduction
melanin biosynthetic process
pigmentation
positive regulation of transcription from RNA polymerase II promoter
regulation of feeding behavior
UV-damage excision repair
positive regulation of cAMP/PKA signal transduction
positive regulation of feeding behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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