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H3.3 G34R oncohistone mutant Recombinant Rabbit Monoclonal Antibody (RM240)
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FIGURE: 1 / 3
H3.3 G34R oncohistone mutant Antibody (MA5-38665) in IHC
Immunohistochemistry of clinically validated FFPE Glioblastoma tumor tissues with H3.3 G34R expression using H3.3 G34R oncohistone mutant Recombinant Monoclonal antibody (Product # MA5-38665). Clinically validated to be Positive for H3.3 G34R Mutation.
Product Details
MA5-38665
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM240
Immunogen
A peptide corresponding to Histone H3.3 G34R mutant
Conjugate
Form
Liquid
Concentration
250 µg/mL
Amount
25 µg
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H3 histone family member 3A; H3 histone family member 3B; H3 histone, family 3A; H3 histone, family 3B (H3.3B); H3.3; H3.3 G34R; H3.3 histone; H3/g; H3B; H3FT; H3t; Histone 3.3; Histone cluster 3; Histone H3; Histone H3.3; Histone H3.3 G34R; Histone H3.3G34R; unnamed protein product
Gene Aliases: BRYLIB1; BRYLIB2; H3-3A; H3-3B; H3.3A; H3.3B; H3F3; H3F3A; H3F3B; PP781
UniProt ID: (Human) P84243
Entrez Gene ID: (Human) 3020, (Human) 3021
oocyte maturation
osteoblast differentiation
nucleosome assembly
nucleus organization
spermatogenesis
spermatid development
single fertilization
embryo implantation
cell proliferation
male gonad development
positive regulation of cell growth
pericentric heterochromatin assembly
telomeric heterochromatin assembly
telomere organization
multicellular organism growth
muscle cell differentiation
oogenesis
regulation of centromere complex assembly
negative regulation of chromosome condensation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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