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Invitrogen
Glypican 3 Recombinant Rabbit Monoclonal Antibody (024), APC
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FIGURE: 1 / 2
Glypican 3 Antibody (MA5-40986) in Flow
Flow cytometric analysis of Human Glypican 3 expression on HepG2 cells. Cells were stained with Glypican 3 Recombinant Rabbit Monoclonal Antibody (024), APC (Product # MA5-40986). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-40986
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
024
Immunogen
A synthetic peptide corresponding to the center region of the Human Glypican 3/GPC3/OCI-5
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.03% ProClin 300
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.
Target Information
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell surface protein; precursor core protein cleaved by furin; glypican proteoglycan 3; Glypican-3; GTR2-2; GTR22; heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; OCI-5; secreted glypican-3; unnamed protein product
Gene Aliases: DGSX; GPC3; GTR2-2; MXR7; OCI-5; OCI5; SDYS; SGB; SGBS; SGBS1
UniProt ID: (Human) P51654
Entrez Gene ID: (Human) 2719
branching involved in ureteric bud morphogenesis
kidney development
smoothened signaling pathway
negative regulation of cell proliferation
response to bacterium
anatomical structure morphogenesis
organ morphogenesis
anterior/posterior axis specification
regulation of signal transduction
body morphogenesis
cell migration
bone mineralization
osteoclast differentiation
lung development
positive regulation of BMP signaling pathway
embryonic hindlimb morphogenesis
regulation of growth
cell migration involved in gastrulation
positive regulation of protein catabolic process
positive regulation of endocytosis
negative regulation of smoothened signaling pathway
positive regulation of smoothened signaling pathway
negative regulation of growth
positive regulation of glucose import
epithelial cell proliferation
negative regulation of epithelial cell proliferation
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
regulation of canonical Wnt signaling pathway
coronary vasculature development
cell proliferation involved in kidney development
mesenchymal cell proliferation involved in ureteric bud development
mesonephric duct morphogenesis
cell proliferation involved in metanephros development
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
regulation of protein localization to membrane
regulation of non-canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway, planar cell polarity pathway
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