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Invitrogen
Nicastrin Recombinant Rabbit Monoclonal Antibody (002), PE
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Product Details
MA5-41000
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
002
Immunogen
Recombinant Human Nicastrin/NCSTN protein (1-669).
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.03% ProClin 300
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.
Target Information
NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anterior pharynx-defective 2; KIAA0253; Nicastrin; OTTHUMP00000031840; type 1 transmembrane protein; unnamed protein product
Gene Aliases: ATAG1874; KIAA0253; NCSTN; UNQ1874/PRO4317
UniProt ID: (Human) Q92542
Entrez Gene ID: (Human) 23385
myeloid cell homeostasis
proteolysis
membrane protein ectodomain proteolysis
dopamine receptor signaling pathway
glutamate receptor signaling pathway
Notch signaling pathway
Notch receptor processing
learning or memory
protein processing
cerebellum development
central nervous system myelination
adult behavior
membrane protein intracellular domain proteolysis
beta-amyloid formation
T cell proliferation
amyloid precursor protein metabolic process
amyloid precursor protein biosynthetic process
positive regulation of amyloid precursor protein biosynthetic process
amyloid precursor protein catabolic process
beta-amyloid metabolic process
epithelial cell proliferation
neuron apoptotic process
cellular response to calcium ion
regulation of long-term synaptic potentiation
short-term synaptic potentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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