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Invitrogen
MSH6 Monoclonal Antibody (A4C4)
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FIGURE: 1 / 17
MSH6 Antibody (MA5-42406) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human gastric adenocarcinoma tissue using MSH6 Monoclonal Antibody (Product # MA5-42406). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the MSH6 antibody at ... View More
Product Details
MA5-42406
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
A4C4
Immunogen
Synthetic peptide corresponding to C-terminal Human MSH6.
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Human skin tissue lysate, rat brain tissue lysate, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human breast carcinoma tissue, human esophagus tissue, human placenta tissue, mouse testis tissue, mouse colon tissue, mouse placenta tissue, human gastric adenocarcinoma tissue, mouse spleen tissue, mouse small intestine tissue, K562.
Subcellular Location: Nucleus, Chromosome.
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; mutS-like protein 6; p160; Sperm associated protein; sperm-associated protein; unnamed protein product
Gene Aliases: AU044881; AW550279; GTBP; GTMBP; HNPCC5; HSAP; LYNCH5; MMRCS3; MSH-6; MSH6; p160
UniProt ID: (Human) P52701, (Mouse) P54276
Entrez Gene ID: (Human) 2956, (Mouse) 17688
nucleotide binding
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
histone H3K36me3 reader activity
ATP-dependent DNA damage sensor activity
ATPase activity
single base insertion or deletion binding
methylated histone binding
DNA metabolism protein
meiotic mismatch repair
DNA repair
mismatch repair
chromatin organization
cellular response to DNA damage stimulus
spermatogenesis
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
intrinsic apoptotic signaling pathway
reciprocal meiotic recombination
positive regulation of helicase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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