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Invitrogen
GluR2/GluR3 Recombinant Rabbit Monoclonal Antibody (4K7G5)
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FIGURE: 1 / 2
GluR2/GluR3 Antibody (MA5-42796) in WB
Western blot analysis of GluR2/GluR3 in extracts of various cell lines. Samples were incubated with GluR2/GluR3 Monoclonal antibody (Product # MA5-42796) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-42796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4K7G5
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 784-883 of human GluR2+GluR3 (P42262).
Conjugate
Form
Liquid
Concentration
1.15 mg/mL
Amount
115 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse brain, Rat brain.
Immunogen sequence: KNKWWYDKGE CGSGGGDSKE KTSALSLSNV AGVFYILVGG LGLAMLVALI EFCYKSRAEA KRMKVAKNAQ NINPSSSQNS QNFATYKEGY NVYGIESVKI
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; GluR-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; glutamate receptor B; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GPRC1C; GRM3; MGR3
Gene Aliases: 2900064I19Rik; GluA2; GluA3; Glur-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3; Gluralpha3; Gria2; Gria3; Kiaa4184
UniProt ID: (Rat) P19491, (Mouse) Q9Z2W9, (Rat) P19492
Entrez Gene ID: (Mouse) 14800, (Rat) 29627, (Mouse) 53623, (Rat) 29628
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
regulation of receptor recycling
transport
ion transport
chemical synaptic transmission
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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